Reinhart described her character's aesthetic as 'slutty Hannah Montana.' A running gag shows Annabelle vomiting in times of stress, and the fake vomit was made of animal crackers and Sprite. Reinhart played Annabelle, 'the baby of the group,' a former stripper who joins Ramona and her crew in drugging and robbing their Wall Street clientele. Reinhart joined the cast of Lorene Scafaria's Hustlers in March 2019. Galveston received mixed critical reviews and grossed only $190,320 at the box office.

The film premiered at South by Southwest on March 10, 2018, and received a limited theatrical release through RLJE Films on October 19, 2018. In the film, directed by Mélanie Laurent, Reinhart plays Tiffany, who was placed for adoption as a child. In 2017, Reinhart was cast in Galveston, based on Nic Pizzolatto's 2010 novel of the same name. Previously, Reinhart worked on the Fox sitcom Surviving Jack. The series premiered on January 26, 2017, and in February 2021, it was renewed for a sixth season. Reinhart auditioned twice for the role, first sending in an audition tape from her North Carolina home before appearing in person a month later. Series creator Roberto Aguirre-Sacasa originally sought out Kiernan Shipka for the role after seeing her work in Mad Men. On February 9, 2016, Reinhart was cast as Betty Cooper in The CW's teen drama television series Riverdale, based on the characters of Archie Comics. She also starred in the films Lilith (2011), Not Waving But Drowning (2012), The Kings of Summer (2013), Gibsonburg (2013), Forever's End (2013), Miss Stevens (2016), and The Good Neighbor (2016). Reinhart starred in the television pilot for Scientastic! (2010) and guest starred on the television series Law & Order: Special Victims Unit (2011).

Reinhart moved to Los Angeles when she was 18 years old to pursue acting and almost gave up after five months. She developed a love for singing, acting, and dancing at the age of 10, and asked her mom to drive her to New York City for auditions. She is of German and French descent and has stated her surname is of German origin. Reinhart was born in Cleveland, Ohio, and raised in the nearby town of Bay Village.

In 2020, she portrayed Grace Town in Chemical Hearts, a film adaptation of the novel Our Chemical Hearts by Krystal Sutherland. She is known for portraying Betty Cooper on The CW teen drama series Riverdale (2017–present) and Annabelle in Lorene Scafaria's black comedy crime drama film Hustlers (2019). Lili Pauline Reinhart (born September 13, 1996) is an American actress.

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